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Rosuvastatin and RM-1 polyphenol effects on insulin resistance, coagulation, and platelet aggregation in diabetic rats

Siroj KhodjiyevInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANGuli M. RaimovaInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANMuhammadqodir Musajonugli OrtiqovInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANIslom B QozoqovInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANJobir I DedaboyevInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANNozim N. KhoshimovInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANKabil E. NasirovInstitute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANAlisher A. MukhtorovNational University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTANNazifa R AchilovaDepartment of Biology, Faculty of Natural Sciences and Medicine, Navoi State University, Navoi, UZBEKISTANSADILLOYEVA LOLA SIROJOVNA

2026

Ochiq kirishOlmos

Litsenziya: cc-by

ABI

Annotatsiya

Background: Type 2 diabetes mellitus is associated with disturbances in carbohydrate and lipid metabolism as well as hemostasis, including hyperfibrinogenemia and enhanced platelet aggregation. Statins, while cardioprotective, may impair insulin secretion and increase insulin resistance (IR). Aim: To evaluate the effects of rosuvastatin alone and in combination with RM-1 polyphenol on IR, lipid and hepatic parameters, coagulation, plasma fibrinogen, and platelet aggregation in a high-fat diet/streptozotocin-induced rat model of type 2 diabetes. Methods: Forty male Wistar rats (280-320 g) were divided into four groups (n = 10 each): intact, diabetic control, diabetic + rosuvastatin (10 mg/kg/day), and diabetic + rosuvastatin + RM-1 (10 mg/kg/day each), treated orally for 4 weeks. Results: Diabetic rats showed marked hyperglycemia, dyslipidemia, elevated liver enzymes, hyperinsulinemia with increased HOMA-IR, shortened APTT and PT, hyperfibrinogenemia (4.4 vs 2.1 g/L in intact rats), and enhanced platelet aggregation. Rosuvastatin partially corrected these parameters; the rosuvastatin + RM-1 combination produced the most consistent improvement, approaching intact-group values, and also improved ALT, AST, low-density lipoprotein, and HDL beyond rosuvastatin alone. Effects on triglycerides and total cholesterol were less uniform. Conclusion: RM-1 polyphenol enhances the corrective effect of rosuvastatin on diabetes-induced glycemic and hemostatic disturbances, supporting its potential as an adjunct therapy.

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DOI: 10.29333/ejgm/19445

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