USE OF LIQUID BIOPSY AS A METHOD FOR MONITORING CERVICAL CANCER RECURRENCE (LITERATURE REVIEW)

Resume. Relevance. Cervical cancer is a serious global health problem affecting women. Despite the implementation of population-based screening programs, vaccination, advances in understanding the pathogenesis of the disease, and improvements in diagnostic methods and treatment strategies, the number of cases continues to increase from year to year. Disease progression, particularly recurrence of cervical cancer, is being observed with increasing frequency. Recurrence of cervical cancer (CC) occurs in 10–40% of cases. In patients with recurrent CC, the five-year survival rate during treatment with modern pharmacological agents is approximately 5–15%. Clinical and morphological characteristics of the tumor process associated with an unfavorable prognosis and an increased risk of CC recurrence are known. The search for molecular prognostic markers of CC progression is ongoing. Cytological screening is not always effective for a number of reasons. Therefore, the search for new predictive markers for the prognosis of cervical cancer recurrence remains highly relevant. Currently, liquid biopsy is considered a promising approach from the perspective of a personalized strategy for the diagnosis and monitoring of cervical cancer. Aim of the study. To analyze available data on the potential use of liquid biopsy in the diagnosis and monitoring of cervical cancer. Materials and Methods. A review of scientific literature on this topic published over the past 10 years and identified through the PubMed and eLibrary databases was conducted. Results. The most extensively studied non-invasive biomarkers of cervical cancer include circulating tumor DNA (ctDNA), RNA, and exosomes. These biomarkers play an important role in cervical carcinogenesis, reflect the course of the disease, and, together with established clinical and morphological prognostic criteria, may contribute to determining the prognosis of cervical cancer. Currently, liquid biopsy is considered a promising modern method for the diagnosis of cervical cancer and monitoring of disease progression. The diagnostic value of this approach is determined by its potential to predict disease course and detect recurrence. Given its considerable diagnostic potential, the possibility of using liquid biopsy as a screening method for cervical cancer in the future cannot be excluded. However, further research in this field is required to confirm such conclusions. Conclusions. The available evidence indicates the potential utility of liquid biopsy as a method for monitoring the course of cervical cancer and detecting its recurrence Keywords cervical cancer (CC), recurrence, metastases, minimal residual disease, liquid biopsy, digital droplet polymerase chain reaction (ddPCR), circulating tumor DNA (ctDNA).

Hali tarjima qilinmagan