O‘tkir respirator infeksiyalarining birinchi tprimestrda o‘homila rivojlanmay qolishiga ta’siri
Litsenziya: cc-by
Annotatsiya
This article presents a pathophysiological, immunological, and clinical analysis of the impact of acute respiratory infections (ARIs) on embryonic development during the first trimester of pregnancy. The first trimester, spanning weeks 3 to 12, is the period of organogenesis, during which the developing embryo exhibits heightened sensitivity to external harmful factors as primary organs and systems are formed. ARIs can adversely affect the fetus through both direct (viral transmission across the placental barrier) and indirect mechanisms, including hyperthermia, systemic inflammation, cytokine activity, hypoxia, and placental dysfunction. Elevated body temperature can disrupt DNA synthesis and cellular proliferation, while hypoxia may lead to embryonic regression or developmental arrest. Furthermore, physiological immunosuppression, the predominance of the Th2 immune response, and mechanical changes in the respiratory system during pregnancy create conditions for a more severe course of infection. Based on epidemiological data, the high burden of ARIs in some regions was assessed using proxy indicators; however, specific regional statistical data for the first trimester require information from the antenatal period. The study results indicate that an ARI in the first trimester can be considered an additional factor that increases the risk of non-developing pregnancy. Therefore, early diagnosis, monitoring, safe treatment strategies, and preventive measures are of critical importance in preventing perinatal complications.