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Endometriy giperplaziyasida sitokin profili va uning metabolik disfunksiya hamda steroid almashinuvi buzilishlari bilan bog‘liqligi: tizimli sharh

Diloram MusakhodjaevaNazokat SharipovaGulzara EshimbetovaAZIZOVA ZukhraInstitute of Immunology and Human Genomics of theNigora ShoikramovaDiloram MusakhodzhaevaИнститут иммунологии и геномики человека Академии наук Республики УзбекистанNazokat SharipovaGulzara EshimbetovaAZIZOVA ZukhraИнститут иммунологии и геномики человека Академии наук Республики УзбекистанNigora ShoikramovaDiloram MusaxodjayevaNazokat SharipovaGulzara YeshimbetovaZukhra S. AzizovaInstitute of Immunology and Human Genomics of theNigora Shoikramova
2026ru
ABI

Annotatsiya

The article systematizes evidence on the cytokine profile in endometrial hyperplasia and its relationship with metabolic and steroid disturbances. The most consistent alterations involve IL-1β, IL-6, and TNF-α, while systemic and local cytokine activity may differ substantially. Insulin resistance appears to be a key metabolic factor, whereas the role of liver metabolic dysfunction through SHBG, steroid metabolism, and systemic inflammation requires further investigation.

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