Homilador ayollarda endotoksikozni kompleks klinik-laborator baholash

Endotoxicosis in pregnant women is a systemic pathological process that occurs in response to the influence of bacterial endotoxins and inflammatory mediators and is accompanied by the development of a systemic inflammatory response, microcirculatory disorders, and endothelial dysfunction. Given the high frequency of infectious and inflammatory complications of gestation and their impact on perinatal outcomes, early diagnosis and objective assessment of the severity of endotoxicosis are of important clinical significance. The aim of this study was to develop and clinically test a comprehensive algorithm for assessing the severity of endotoxicosis in pregnant women based on clinical, biochemical, and instrumental parameters. A prospective comparative study included 120 pregnant women at 22–38 weeks of gestation, of whom 80 patients had clinical and laboratory signs of endotoxicosis and 40 women with a physiological pregnancy comprised the control group. A statistically significant increase in the levels of C-reactive protein, procalcitonin, interleukin-6, lactate, and medium-weight molecules was found in patients of the main group compared with the control group (p < 0.001). The developed integral index of endotoxicosis demonstrated high diagnostic value (AUC = 0.87; 95% CI 0.79–0.94). The obtained data confirm the feasibility of a comprehensive clinical and laboratory assessment for early risk stratification of pregnancy complications.

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