Pathogenesis of Cervical Cancer

Cervical cancer is one of the diseases with the highest global mortality rate among women. This article analyzes the pathophysiological mechanisms of cervical carcinogenesis at the molecular and cellular levels. Highly oncogenic HPV infection, E6/E7 oncoproteins, inactivation of p53 and Rb pathways, genomic instability, epigenetic modifications, immune evasion and changes in the stromal microenvironment are considered as key processes. In-depth study of the pathophysiology allows for early diagnosis, development of individual treatment strategies and effective implementation of preventive measures.

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