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Membranous-pattern Nephropathy with Monotypic IgA1-κ Deposits: A Rare Case Report

Xiaotao MaDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaXiangfei YaoDepartment of Nephrology, Xi’an Gaoxin Hospital, Xi'an, Shaanxi, ChinaTian YaoDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaYang XiaDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaLanmei JingDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaYu FanDepartment of Pathology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, ChinaChangqing FanDepartment of Pathology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, ChinaJiarong MaoDepartment of Pathology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, Shaanxi, ChinaJing XuDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaHeng GeDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaAkhmedova Nilufar SharipovnaDepartment of Nephrology, Bukhara State Medical Institute, Bukhara, UzbekistanRongguo FuDepartment of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

2026en

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Annotatsiya

Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome, characterized by the deposition of subepithelial immune complexes1. In primary MN, these complexes are typically polytypic, composed of polyclonal immunoglobulins. Rare cases of MN with light chain–restricted deposits have been reported 2,3. In contrast to Randall-type monoclonal immunoglobulin deposition disease, which features punctate deposits along the inner glomerular basement membrane, these patients exhibit membranous granular deposits.

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DOI: 10.1016/j.kintcr.2026.100169

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