Endotelial disfunksiya sharoitida tabiiy bioaktiv birikmalarning miokard remodellanishiga ta’sirining eksperimental-patofiziologik mexanizmlari
Litsenziya: cc-by
Annotatsiya
This article analyzes the experimental pathophysiological mechanisms underlying the effects of natural bioactive compounds on myocardial remodeling under conditions of endothelial dysfunction. The study aims to identify the relationship between impaired endothelial function, oxidative stress, and inflammatory processes, on the one hand, and structural and functional changes in the myocardium, on the other. To this end, relevant scientific literature is comparatively analyzed, and experimental parameters used to assess the effects of natural bioactive compounds are summarized. The biological activity of nitric oxide, endothelium-dependent vascular responses, cardiomyocyte status, collagen accumulation, and the degree of fibrosis are considered as interrelated assessment criteria. The article is based on a review of the scientific literature and does not present new experimental findings on any specific bioactive compound.