Iron based Nanoparticle-Driven Green Catalysis for Functionalized Indole Synthesis: Recent Advancements and Mechanistic Insights

Abstract: The synthesis of indole derivatives is of enormous significance in the fields of medical and synthetic organic chemistry. This is due to the fact that indole derivatives are frequently found in a wide variety of natural products and pharmaceuticals, as well as their vast biological activity. During the past few years, Fe-based NPs have gained recognition as catalysts that are not only efficient but also sustainable and cost-effective for the synthesis of indole frameworks. This approach offers a multitude of advantages, such as a wide catalyst surface area, the capability of being magnetically retrieved as a nanocatalyst, low toxicity, exceptional catalytic effectiveness, and mild reaction conditions. Fe-NPs have been successfully explored to create a wide variety of indole derivatives with high yields in a short duration. These transformations include Fischer indole synthesis, cyclization, and multicomponent processes. This review highlights the growing significance of Fe-based NPs as a nanocatalyst for indole synthesis.

Hali tarjima qilinmagan