Evaluation Of The Efficacy Of Platelet-Rich Plasma Therapy In The Treatment Of Knee Osteoarthritis

Background: Knee osteoarthritis is a common degenerative joint disease that causes chronic pain, functional disability, and impaired quality of life. Platelet-rich plasma (PRP) therapy has emerged as a promising biological treatment because of its regenerative and anti-inflammatory properties. Objective: To evaluate the efficacy of platelet-rich plasma therapy in the treatment of knee osteoarthritis. Methods: This retrospective observational study was conducted at Liaquat University of Medical and Health Sciences from May 20205 to May 2026 and included 120 patients with symptomatic knee osteoarthritis who received intra-articular PRP injections. Results: The mean age of patients was 58.4 ± 8.7 years, and 72 (60.0%) were female. Baseline VAS, WOMAC, and KOOS scores were 7.8 ± 1.1, 58.6 ± 10.7, and 48.3 ± 11.5, respectively. At six months, VAS pain score significantly decreased to 3.6 ± 1.3, WOMAC improved to 31.2 ± 9.4, and KOOS increased to 72.5 ± 10.8 (all p<0.001). Knee flexion improved from 111.4 ± 10.2° to 122.8 ± 8.6°, while analgesic use declined from 77.5% to 29.2%. Overall, 98 (81.7%)patients reported good or excellent satisfaction. Minor adverse events included transient injection-site pain (15.0%), mild joint swelling (10.0%), and knee stiffness (7.5%), with no infections or allergic reactions observed. Conclusion: Platelet-rich plasma therapy provides significant pain relief, functional improvement, and excellent safety in patients with knee osteoarthritis. Earlier disease stage, younger age, lower body mass index, shorter symptom duration, and absence of diabetes mellitus are associated with superior clinical outcomes following PRP therapy..

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