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Can grip strength capture what chair standing does? methodological considerations on functional measures and successful aging in three international cohorts

Kudratova ZeboDepartment of Clinical Laboratory Diagnostics, Samarkand State Medical University, Samarkand, UzbekistanAzamat KarabaevDepartment of Pathological Physiology, Physiology and Hygiene, Zarmed University, Samarkand, UzbekistanVazira RaxmanovaBukhara State Pedagogical Institute, Bukhara, UzbekistanA. (A) SadykovaTashkent State Medical University, Tashkent, UzbekistanShahlo AxmadjonovaDepartment of Communal and Occupational Hygiene, Fergana Medical Institute of Public Health, Fergana, UzbekistanFarzan Vira BagheriSchool of Medicine, Guilan University of Medical Sciences, Rasht, Iran. [email protected]

2026en

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Litsenziya: cc-by-nc-nd

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Annotatsiya

Population aging has accelerated globally, making successful aging a key public health priority. Zhuang and Gao address the prospective association between cumulative average grip strength and successful aging using three international cohorts. While their multi-cohort design offers valuable cross-population insights, several methodological choices warrant consideration. Grip strength may not fully capture functional determinants of successful aging. Self-reported chronic disease introduces misclassification bias varying across socioeconomic groups. The two-stage temporal design does not fully address selection bias and cross-cohort comparability from heterogeneous exposure windows. Additionally, the cohort-relative cognitive threshold undermines cross-population comparability. These considerations highlight the need for methodological reflection and suggest directions for strengthening future multi-cohort studies.

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DOI: 10.1007/s40520-026-03523-z

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