Фронто-темпоральная деменция и биохимические маркеры

Here we discuss the problems of fronto-temporal dementia, its clinical picture in patients in Uzbekistan and the results of our investigation of the possible associations between clinical features of frontotemporal dementia and the level of the hormone dehydroepiandrosterone sulfate.Material and methods.Three groups of patients aged 60 to 75 years, with fronto-temporal dementia, chronic brain ischemia and a healthy control group, were examined.They underwent physical examination, complete neurological clinical testing, including an assessment of cognitive functions using neuropsychological scales, and a blood test for the level of the hormone dehydroepiandrosterone sulfate was performed.Results.The clinical presentation of fronto-temporal dementia in our patients in Uzbekistan was similar to other populations.The lowest level of the hormone dehydroepiandrosterone sulfate was observed in the group of patients with frontotemporal dementia -1.25 mcg/ml, and the highest -in the group of healthy controls -2.29 mcg/ml.Conclusion.This study demonstrates the existence of a potential association between the development of cognitive impairment and the concentration of the hormone dehydroepiandrosterone sulfate in the blood.It could be tested in the future studies and used for individualized approaches in pharmacotherapy and non-pharmacological interventions.

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