Strategic development of benzimidazole-derived glycosidase modulators for antihyperglycemic intervention: a comprehensive medicinal study integrating molecular docking, biological evaluation, in vivo validation and pharmacokinetic assessment
Zanib FiazDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad-22500, PakistanShoaib Khan SwatiDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad-22500, PakistanTayyiaba IqbalDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad-22500, PakistanKhurram ShoaibDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad-22500, PakistanMasi A. AlmalkiDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Saudi ArabiaFaez S. AlotaibiDepartment of Chemistry, College of Science, Qassim University, Buraydah, Saudi ArabiaKhasan KayumovNational University of Uzbekistan named after Mirza Ulugbek, Tashkent, UzbekistanSouhir AbidDepartment of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi ArabiaMajdi AbidDepartment of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi ArabiaSobhi GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi ArabiaMagdi E. A. ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia
2026en
Ochiq kirishYashil
ABI
Annotatsiya
We applied an integrated computational–biological framework to identify benzimidazole-based thiophene-derived bis-Schiff base derivatives as potential antidiabetic agents targeting α-amylase and α-glucosidase.
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