Metabolik yosh: melatoninning salomatlik va tana vazniga ta’siri

The article investigates the relationship between nocturnal salivary melatonin levels, metabolic age, and body composition parameters in individuals with varying degrees of obesity. The study included 60 participants divided into four groups: a normal-weight control group and groups with class I, II, and III obesity. Melatonin levels were determined in saliva samples collected during the nighttime interval from 02:00 to 03:00 and stored at −20 °C until analysis. Metabolic age and body composition parameters were assessed using bioelectrical impedance analysis performed in the fasting state, with physical activity restricted for 24 hours before the examination. A decrease in nocturnal melatonin levels was identified with increasing obesity severity. A negative association was found between melatonin concentration and metabolic age. These findings support the consideration of melatonin as a potential marker of obesity-associated metabolic abnormalities.

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