TECHNOLOGY FOR THE DEVELOPMENT OF A NANOSTRUCTURED ANTI-INFLAMMATORY OINTMENT BASED ON POT MARIGOLD (CALENDULA OFFICINALIS L.)

Calendula officinalis L. (pot marigold) is a medicinal plant widely investigated for its phytochemical composition and potential applications in topical pharmaceutical preparations. Its flowers contain several classes of biologically active compounds, including triterpenoids, flavonoids, carotenoids, and phenolic compounds, which may contribute to its antioxidant and anti-inflammatory properties. Conventional topical preparations containing calendula extracts have been used traditionally for minor skin inflammation and wound care. However, the development of standardized formulations requires careful consideration of extract quality, physicochemical stability, drug release, and skin compatibility. Nanotechnology offers potential approaches to improve the dispersion of plant-derived constituents and modify their release from semisolid dosage forms. This article reviews the scientific rationale for developing a nanostructured anti-inflammatory ointment based on C. officinalis L. and proposes a formulation-development framework involving raw material standardization, extract preparation, selection of a suitable nanocarrier, incorporation into an ointment base, and comprehensive quality assessment. Particular attention is given to particle size, polydispersity, zeta potential, rheological properties, in vitro release, skin permeation, microbiological quality, and stability. The proposed approach requires experimental validation to establish formulation performance, safety, and potential therapeutic value.

Hali tarjima qilinmagan