Evaluation Of Laboratory Changes During Long-Term Use Of Anticoagulants

As is often the case in medicine, the use of oral anticoagulants began by chance. The history of their discovery is connected with the diagnosis of a strange hemorrhagic diathesis observed in cattle in North America and Canada at the beginning of the 20th century. In the 1920s, works appeared explaining this disease by prothrombin inactivation in the blood, which appeared when cows ate rotten hay. The correct diagnosis was made only after A. Quick discovered a method for determining prothrombin time in 1935. The results of this test showed that the cause of fatal bleeding in animals was the inactivation of prothrombin complex factors, and the toxic substance isolated from rotten hay was characterized as 4-hydroxycoumarin and called "dicumarol".

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