Прогностическое значение клинико-демографических характеристик и гематологических индексов (NLR, PLR, SII) при раке щитовидной железы

Objective: To analyze clinical and demographic characteristics together with hematological indices to improve the diagnosis and prediction of the clinical course of thyroid cancer (TC). Materials and Methods: The study included 94 patients with morphologically confirmed TC. Age, sex, disease stage, histological tumor type, and hematological markers of systemic inflammation, including NLR, PLR, and SII, were evaluated. Results: Women predominated in the study population (83.0%), as did young adults aged 18–44 years (37.2%) and middle-aged adults aged 45–59 years (29.8%). Highly differentiated carcinomas accounted for 73.4% of cases. Analysis of the hematological data revealed statistically significant increases in all three indices in patients with stage IV TC compared with those with stage III disease: NLR increased 2.17-fold (p = 0.006), PLR 1.60-fold (p < 0.001), and SII 1.32-fold (p < 0.001). Conclusion: Elevated NLR, PLR, and SII values are associated with tumor progression and reflect the severity of systemic immune-inflammatory activity. The use of these parameters as readily available integrative markers may improve the accuracy of risk stratification and facilitate monitoring of treatment efficacy in patients with TC.

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