STUDY OF THE SYNTHESIS, MOLECULAR STRUCTURE, AND BIOLOGICAL ACTIVITY OF "TIOTSIN"
Annotatsiya
Nowadays, diabetes mellitus has become one of the most serious global public health problems. The development of new medicinal products for its prevention and treatment is an urgent task. The aim of this study was to synthesize a novel zinc(II) coordination compound based on α-lipoic acid, “Tiotsin”, and to investigate its structure and biological activity. “Tiotsin” was synthesized with a yield of 86.07%. Elemental analysis, IR spectroscopy, powder X-ray diffraction, differential thermal and thermogravimetric analyses, and DFT quantum-chemical calculations showed that its composition corresponds to [Zn(LIP)(CH₃COO)(H₂O)₂]. The oral LD₅₀ of “Tiotsin” in mice was 1387 (843.3–1845) mg/kg. The antidiabetic activity of “Tiotsin” was evaluated at doses of 70 and 140 mg/kg in a type 2 diabetes mellitus model induced by streptozotocin and nicotinamide. The substance was found to increase insulin secretion and decrease the level of malondialdehyde, a biomarker of oxidative stress. The obtained data indicate that “Tiotsin” is a promising antidiabetic agent and confirm the need for further in-depth investigation of its pharmacological properties. Keywords: “Tiotsin”, α-lipoic acid, zinc, diabetes mellitus, streptozotocin.