Роль мелатонина в коррекции нарушений сна и углеводного обмена у больных репродуктивного возраста с сахарным диабетом 2 типа

Objective: To study the effect of melatonin on sleep quality and glycemic control in patients of reproductive age with type 2 diabetes mellitus (T2DM). Materials and Methods:This prospective randomized study included 120 patients with T2DM aged 25-45 who had sleep disturbances.The patients were divided into two groups: the main group (n=60), which received 3 mg of melatonin at bedtime for 12 weeks, and the control group (n=60), which received a placebo.Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), along with levels of HbA1c, fasting glucose, insulin, and the HOMA-IR index.Results: The main group showed a significant improvement in sleep quality (PSQI score decreased from 12.4±2.1 to 6.8±1.5, p<0.001), a reduction in HbA1c from 8.2±1.1% to 7.1±0.9%(p<0.001), and an improvement in insulin resistance markers.No significant changes were observed in the control group.Conclusion: Melatonin administration in patients of reproductive age with T2DM improves sleep quality and glycemic control, and can be considered an adjunctive method in combination therapy.

Hali tarjima qilinmagan