Parkinson kasalligi va 2-tip qandli diabet komorbidligi: umumiy patogenetik mexanizmlar va genetik-yallig‘lanish biomarkerlarining ahamiyati (adabiyotlar sharhi)
Litsenziya: cc-by
Annotatsiya
Drawing on international and local publications from the past ten years, this review examines the association between Parkinson’s disease (PD) and type 2 diabetes mellitus (T2DM). Large cohort studies and meta-analyses indicate that T2DM increases the risk of developing PD by approximately 25%, while Mendelian randomisation studies suggest a causal relationship. In patients with comorbid PD and T2DM, motor impairment is more severe and cognitive decline is more rapid. The review discusses shared pathogenic mechanisms, including brain insulin resistance, α-synuclein glycation, and neuroinflammation, as well as associations between the GBA and LRRK2 genes and metabolic pathways. The diagnostic value of neurofilament light chain (NfL), IL-6, TNF-α, and C-reactive protein in patients with both conditions, together with the challenges of interpreting these biomarkers, is also examined.