Bolalarda surunkali diareya: klinik belgilar va bosqichma-bosqich tekshiruvning diagnostik ahamiyati

The aim of this study was to summarize scientific literature published between 2016 and 2026 on the clinical assessment and diagnostic evaluation of children with chronic diarrhea. A targeted narrative review of scientific studies, clinical guidelines, and diagnostic algorithms was conducted. The findings indicate that assessing clinical manifestations and changes in a child’s physical growth and development is important for determining further diagnostic strategies. In a study involving 90 children referred for specialist evaluation, increasing the fecal calprotectin threshold from >50 to >250 µg/g was associated with a decrease in diagnostic sensitivity from 99% to 81% and an increase in specificity from 84% to 98%. These values reflect the diagnostic performance of the test in this particular sample and cannot be regarded as universal diagnostic criteria. Thus, the evaluation of children with chronic diarrhea should be based on comprehensive clinical assessment and the targeted use of laboratory and instrumental investigations. However, a normal fecal calprotectin level does not exclude celiac disease or other organic causes of chronic diarrhea.

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