Vasorelaxant Effect of Copsinine and N4-Iodine Methylate Copsinin Alkaloids
Lazizbek Sodiqjonovich. YunusovAndijan State University , UzbekistanAnvar ZaynabiddinovAndijan State University , UzbekistanSh. M. AdizovInstitute of Chemistry of Plant Substance named after academician S Yunusov Academy of Sciences of Uzbekistan , UzbekistanErgashboy KhalilovAndijan State University , UzbekistanFazliddin AhmedovAndijan State University , UzbekistanAzizbek MutalipovAndijan State University , UzbekistanUlugbek GayibovA.S.Sadykov Institute of Bioorganic Chemistry
2020en
Ochiq kirishOltin
ABI
Annotatsiya
In the present research, it has been studied the vasorelaxant effect of the copsinine alkaloid and it's derivative N4-iodomethylate copsinin isolated from the aerial parts of the plant Vinca erect in isometric conditions and analyzed the chemical structure-activity relationship of biological activity on the smooth muscles of the rat aortic blood vessel.In experiments, it was obtained that the vasorelaxant effect of copsinine and N4-iodomethylate copsinine depend on their concentration and chemical structure as well as with blockade of 2 L Ca + channels in the plasma membrane of smooth muscle cells of blood vessels.
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