A highly swellable carboxymethyl cellulose composite hydrogel for obesity intervention in diet-induced obese mice
Yan ZhouSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaRufei GeInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou 310018, ChinaKhaydar E. YunusovInstitute of Polymer Chemistry and PhysicsAbdumutolib Abdupatto Ugli AtakhanovInstitute of Polymer Chemistry and PhysicsUladzislau E. AharodnikauResearch Institute for Physical Chemical Problems of the Belarusian State University, Minsk, BelarusSergey O. SolomevichResearch Institute for Physical Chemical Problems of the Belarusian State University, Minsk, BelarusLei NieCollege of Life Sciences, Xinyang Normal University, Xinyang 464000, ChinaJianbo ZhaoEngineering Laboratory of Chemical Resources Utilization in South Xinjiang of Xinjiang Production and Construction Corps, College of Chemistry and Chemical Engineering, Tarim University, Alar, 843300, ChinaGuohua JiangSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
2026en
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results showed that the developed hydrogels could effectively slow down weight gain and reduce liver fat accumulation, lipid levels, and inflammatory responses. The 16S rRNA gene sequencing revealed that the high-fat diet mice exhibited a significant increase in the relative abundance of Firmicutes and a decrease in Bacteroidetes at the phylum level, leading to an elevated Firmicutes/Bacteroidetes (F/B) ratio.
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