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Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery

Patricia HorcajadaUniversité de MontpellierChristian SerreInstitut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain, Institut Charles Gerhardt, UMR CNRS 5253, UM2, ENSCM, Université de Montpellier II, 34095 Montpellier Cedex 5, France, Tectospin group of Institut Lavoisier & NMRtec Versailles, France, and Institut Universitaire de France, Paris, FranceGuillaume MaurinInstitut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain, Institut Charles Gerhardt, UMR CNRS 5253, UM2, ENSCM, Université de Montpellier II, 34095 Montpellier Cedex 5, France, Tectospin group of Institut Lavoisier & NMRtec Versailles, France, and Institut Universitaire de France, Paris, FranceNaseem A. RamsahyeInstitut Universitaire de FranceFrancisco BalasInstitut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain, Institut Charles Gerhardt, UMR CNRS 5253, UM2, ENSCM, Université de Montpellier II, 34095 Montpellier Cedex 5, France, Tectospin group of Institut Lavoisier & NMRtec Versailles, France, and Institut Universitaire de France, Paris, FranceMaría Vallet‐RegíInstitut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain, Institut Charles Gerhardt, UMR CNRS 5253, UM2, ENSCM, Université de Montpellier II, 34095 Montpellier Cedex 5, France, Tectospin group of Institut Lavoisier & NMRtec Versailles, France, and Institut Universitaire de France, Paris, FranceMuriel SebbanUniversité de MontpellierFrancis TaulelleCentre National de la Recherche ScientifiqueGérard FéreyInstitut Charles Gerhardt Montpellier

2008en

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ABI

Annotatsiya

Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.

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DOI: 10.1021/ja710973k

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