Maqola

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

Jun Z. LiDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305–5120, USADevin M. AbsherDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305–5120, USAHua TangDepartment of Biological Sciences, Stanford University, Stanford, CA 94305–5120, USAAudrey M. SouthwickDepartment of Biological Sciences, Stanford University, Stanford, CA 94305–5120, USAAmanda M. CastoDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305–5120, USASohini RamachandranDepartment of Biological Sciences, Stanford University, Stanford, CA 94305–5120, USAHoward M. CannDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305–5120, USAGregory S. BarshDepartment of Biological Sciences, Stanford University, Stanford, CA 94305–5120, USAMarcus W. FeldmanDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305–5120, USALuigi Luca Cavalli-SforzaDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305–5120, USAR MyersDepartment of Biological Sciences, Stanford University, Stanford, CA 94305–5120, USA

2008en

Ochiq kirish: yoʻq

ABI

Annotatsiya

Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations of the Human Genome Diversity Panel at 650,000 common single-nucleotide polymorphism loci. Individual ancestry and population substructure were detectable with very high resolution. The relationship between haplotype heterozygosity and geography was consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa. In addition, we observed a pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions. This data set allows the most comprehensive characterization to date of human genetic variation.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1126/science.1153717

Iqtiboslar va manbalar

7 ta iqtibos0 ta foydalanilgan manba