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Clustal W and Clustal X version 2.0

Mark LarkinEuropean Molecular Biology LaboratoryGordon BlackshieldsEuropean Molecular Biology LaboratoryNigel P. Brown1 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland, 2Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, 3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UKR. Chenna1 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland, 2Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, 3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UKPaul McGettigan1 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland, 2Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, 3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UKHamish McWilliam1 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland, 2Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, 3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UKF. ValentinEuropean Bioinformatics InstituteIain M. WallaceEuropean Bioinformatics InstituteAndreas WilmEuropean Bioinformatics InstituteRodrigo LópezEuropean Molecular Biology LaboratoryJulie ThompsonEuropean Molecular Biology LaboratoryToby J. GibsonEuropean Bioinformatics InstituteDesmond G. Higgins1 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland, 2Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, 3European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UK

2007en

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SUMMARY: The Clustal W and Clustal X multiple sequence alignment programs have been completely rewritten in C++. This will facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems. AVAILABILITY: The programs can be run on-line from the EBI web server: http://www.ebi.ac.uk/tools/clustalw2. The source code and executables for Windows, Linux and Macintosh computers are available from the EBI ftp site ftp://ftp.ebi.ac.uk/pub/software/clustalw2/

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DOI: 10.1093/bioinformatics/btm404

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