CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Rodolphe BarrangouDanisco USA Inc., 3329 Agriculture Drive, Madison, WI 53716, USAChristophe FremauxDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceHélène DeveauDanisco USA Inc., 3329 Agriculture Drive, Madison, WI 53716, USAMelissa RichardsDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FrancePatrick BoyavalDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceSylvain MoineauDanisco USA Inc., 3329 Agriculture Drive, Madison, WI 53716, USADennis RomeroDanisco USA Inc., 3329 Agriculture Drive, Madison, WI 53716, USAPhilippe HorvathDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, France
2007en
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ABI
Annotatsiya
Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophages. We found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus, CRISPR, together with associated cas genes, provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity.
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