Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. KunkleJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. [email protected]The European Alzheimer’s Disease Initiative (EADI),Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceBenjamin Grenier‐BoleyUniv. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, FranceRebecca SimsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAJoshua C. BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAVincent DamotteInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceAdam C. NajDepartment of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAAnne BolandCEA Paris-SaclayMaria VronskayaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsSven J. van der LeeDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsAlexandre Amlie‐WolfInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceCéline BellenguezUniv. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, FranceAura FrizattiDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKVincent ChourakiInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceEden R. MartinNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, BelgiumKristel SleegersDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKNandini BadarinarayanDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKJóhanna JakobsdóttirJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USAKara L. Hamilton‐NelsonResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, SpainSonia Moreno–GrauCentre National de Recherche en Génomique HumaineRobert OlasoCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceRachel RaybouldDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USAYuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USAAmanda B KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandTaniesha MorganDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsShahzad AhmadTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USABadri N. VardarajanDepartment of Neurology, Columbia University, New York, NY, USAJacques EpelbaumUMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, FrancePer HoffmannDivision of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, SwitzerlandMerçé BoadaJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USAGary W. BeechamJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USAJean-Guillaume GarnierCEA Paris-SaclayDenise HaroldDepartment of Family Medicine, University of Washington, Seattle, WA, USAAnnette L. FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, WA, USAOtto ValladaresCentre National de Recherche en Génomique HumaineMarie-Laure MoutetUK Dementia Research InstituteAmy GerrishDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UKAlbert V. SmithUSF Health Byrd Alzheimer's InstituteLiming QuUniversity of PennsylvaniaDelphine BacqCEA Paris-SaclayNicola DenningBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USAXueqiu JianPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAYi ZhaoPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMaria Del ZompoSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyNick C. FoxResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, SpainSeung‐Hoan ChoiInstituto de Investigación Marqués de ValdecillaIgnacio MateoInstituto de Investigación Marqués de ValdecillaJoseph T. HughesDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKHieab H.H. AdamsPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAJohn MalamonPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAFlorentino Sánchez-GarcíaDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKYogen PatelCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAJennifer A. BrodyPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USABeth A. DombroskiPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMaría Cándida Déniz NaranjoDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceMakrina DaniilidouDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceGuðný EiríksdóttirIcelandic Heart Association, Kopavogur, IcelandShubhabrata MukherjeeUniversité de Rouen NormandieDavid WallonUniversité de Rouen NormandieJames UphillDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UKThor AspelundIcelandic Heart Association, Kopavogur, IcelandLaura B. CantwellCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceFabienne GarziaCEA Paris-SaclayDaniela GalimbertiUniversity of Milan, Centro Dino Ferrari, Milan, ItalyEdith HoferInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, AustriaMariusz ButkiewiczCEA Paris-SaclayBertrand FinCentre National de Recherche en Génomique HumaineElio ScarpiniFerrari (Italy)Chloé SarnowskiInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USAWilliam S. BushCEA Paris-SaclayStéphane MeslageCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceJohannes KornhuberProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USACharles C. WhiteInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USAYuenjoo SongDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USARobert C. BarberUniversity of North Texas Health Science CenterSebastiaan EngelborghsLaboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumSabrina SordonDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyDina VoijnovicDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USAPerrie M. AdamsDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USARik VandenbergheLaboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, BelgiumManuel MayhausDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyL. Adrienne CupplesFramingham Heart Study, Framingham, MA, USAMarilyn S. AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USAPeter Paul De DeynLaboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumWei GuDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyJ.J. HimaliDepartment of Neurology, Boston University School of Medicine, Boston, MA, USADuane BeeklySection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyAlessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyAnnette M. HartmannDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, GermanyAdelina OrellanaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USADeborah BlackerInstituto de Investigación Marqués de ValdecillaEloy Rodríguez‐RodríguezCentro de Investigación Biomédica en RedSimon LovestoneLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USAMelissa E. GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USARachelle S. DoodyAlzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USACarmen Munoz-FernadezDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, SpainRebecca SussamsSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USAHonghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USAThomas FairchildHospital Universitario de Gran Canaria Doctor Negrín
2019en
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