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Stimuli-responsive transdermal microneedle patches

Pooyan MakvandiPiaggio Aerospace (Italy)Rezvan JamaledinCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyGuojun ChenMcGill University Health CentreZahra BaghbantaraghdariUniversity of Naples Federico IIEhsan Nazarzadeh Zare‬School of Chemistry, Damghan University, Damghan, 36716-41167, IranConcetta Di NataleDepartment of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, Naples, 80125, ItalyValentina OnestoCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyRaffaele VecchioneCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyJesse LeeDepartment of Biomedical Engineering, and the Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, H3G 0B1, CanadaFranklin R. TayCollege of Graduate Studies, Augusta University, Augusta, GA, 30912, USAPaolo A. NettiUniversity of Naples Federico IIVirgilio MattoliItalian Institute of TechnologyAna JaklenecDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USAZhen GuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR ChinaRóbert LangerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

2021en

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Litsenziya: cc-by

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Annotatsiya

Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.

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DOI: 10.1016/j.mattod.2021.03.012

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