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<p>Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review</p>

Jie LiCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of ChinaJiaqian ZhaoEngineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou, Zhejiang, People's Republic of ChinaTiantian TanHolistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of ChinaMengmeng LiuKey Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of ChinaZhaowu ZengHolistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of ChinaYiying ZengEngineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou, Zhejiang, People's Republic of ChinaLele ZhangSchool of Medicine, Chengdu University, Chengdu, People's Republic of ChinaChaomei FuCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of ChinaDajing ChenEngineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou, Zhejiang, People's Republic of ChinaTian XieHolistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of China
2020en
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Annotatsiya

Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood-brain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.

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DOI
10.2147/ijn.s243223

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