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Roles of Albumin‐Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery

Pengfei ZhaoZhejiang Academy of Medical Science 182 Tianmushan Road Hangzhou 310013 P.R. ChinaYonghui WangState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 P.R. ChinaAihua WuState Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 P.R. ChinaYuefeng RaoThe First Affiliated Hospital of the College of Medicine, Zhejiang University, Hangzhou, 310003 P.R. ChinaYongzhuo HuangUniversity of Chinese Academy of Sciences Beijing 100049 P.R. China

2018en

Ochiq kirish: yoʻq

ABI

Annotatsiya

Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin-binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor-specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin-based biomimetic tumor-targeted delivery through the ABP pathway is presented.

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Identifikatorlar

DOI: 10.1002/cbic.201800201

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