Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis.
Huiqin BianJiangsu University of Science and TechnologyYu GuDepartment of Hematology, Affiliated People's Hospital of Jiangsu University Zhenjiang 212001, Jiangsu, ChinaChen ChenDepartment of Hematology and Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, ChinaJinnan ChenJiangsu University of Science and TechnologyFei ZhangDepartment of Hematology and Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, ChinaZhonghai XuJiangsu University of Science and TechnologyQian WangDepartment of Hematology and Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, ChinaRui MiJiangsu University of Science and TechnologyXuan WuJiangsu University of Science and TechnologyYaojuan LuDepartment of Hematology and Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, ChinaQiping ZhengShenzhen Walgenron Bio-Pharm Co., Ltd. Shenzhen 518118, Guangdong, ChinaJunxia GuDepartment of Hematology and Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University Zhenjiang 212013, Jiangsu, China
2023en
Ochiq kirishYashil
ABI
Annotatsiya
-silenced cisplatin-exposed cells, indicating that cell cycle progression was inhibited. In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.
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