Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jesse M. JaynesCollege of Agriculture, Environment and Nutrition Sciences, Integrative Biosciences Program, Tuskegee University, Tuskegee, AL 36088, USARushikesh SableCenter for Cancer ResearchMichael RonzettiNational Center for Advancing Translational SciencesWendy BautistaCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USAZachary KnottsCenter for Cancer ResearchAbisola Abisoye-OgunniyanDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USADandan LiRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USARaul CalvoNational Center for Advancing Translational SciencesMyagmarjav DashnyamNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USAAnju SinghNational Center for Advancing Translational SciencesTheresa M. GuerinCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USAJason WhiteDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USASarangan RavichandranAdvanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USAParimal KumarSequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USAKeyur TalsaniaCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USAVicky ChenCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USAAnghesom GhebremedhinTuskegee UniversityBalasubramanyam KaranamDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USAAhmad Bin SalamTuskegee UniversityRuksana AminTuskegee UniversityTaivan OdzorigCenter for Cancer ResearchTaylor AikenDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USAVictoria NguyenRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USAYansong BianRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USAJelani C. ZarifDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USAAmber E. de GrootJohns Hopkins HospitalMonika MehtaSequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USALixin FanBasic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick, MD 21701, USAXin HuNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USAAnton SimeonovNational Center for Advancing Translational SciencesNathan PateCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USAMones Abu‐AsabSection of Histopathology, National Eye Institute, Bethesda, MD 20892, USAMarc FerrerNational Center for Advancing Translational SciencesNoel SouthallNational Center for Advancing Translational SciencesChan-Young OckDepartment of Hemato Oncology, Seoul National University Hospital, Seoul 03080, KoreaYongmei ZhaoCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USAHenry LopezMuriGenics Inc., Vallejo, CA 94592, USASerguei KozlovCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USANatalia de ValCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USAClayton YatesTuskegee UniversityBolormaa BaljinnyamNational Center for Advancing Translational SciencesJuan MarugánNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA
2020en
Ochiq kirishYashil
ABI
Annotatsiya
patient-derived xenotransplantation models. Mechanistically, via selective reduction of immunosuppressive M2-like TAMs, RP-182 improved adaptive and innate antitumor immune responses, including increased cancer cell phagocytosis by reprogrammed TAMs.
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