Synthesis and Characterization of Acetylene Alcohols Via Alkynylation of Heteroatomic Aldehydes with Phenylacetylene Under Various Reaction Parameters Completed with Spatial Chemical Structure, Literature Review, and Bibliometric Analysis

This study explores the synthesis of novel acetylene alcohols via the alkynylation of heteroatomic aldehydes with phenylacetylene using a ProPhenol/Me₂Zn catalytic system. The research systematically investigates key reaction parameters, including reaction duration and temperature, to optimize product yield and selectivity. A detailed reaction mechanism was developed based on these findings. The reactivity of various heteroatomic aldehydes in the alkynylation reaction was analyzed, revealing a reactivity trend influenced by electronic and steric effects. This ranking provides valuable insights into the selectivity of acetylene alcohol formation. The synthesized acetylene alcohols were thoroughly characterized using ¹H-NMR and ¹³C-NMR (structural elucidation). Additionally, a comprehensive literature review and bibliometric analysis were conducted to contextualize the study within existing research, highlighting trends, advancements, and future directions in the field of acetylene alcohols. These findings contribute to a better understanding of alkynylation chemistry and its applications in organic synthesis and material science.

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