Synthesis of Fungal Glycolipid Asperamide B and Investigation of Its Ability to Stimulate Natural Killer T Cells
Vinod ChaudharyDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, United States, and Division of Immunology and Allergy, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United StatesLee A. AlbackerHarvard UniversityShenglou DengHarvard UniversityYa-Ting ChuangHarvard UniversityYubo LiHarvard UniversityDale T. UmetsuHarvard UniversityPaul B. SavageHarvard University
2013en
Ochiq kirish: yoʻq
ABI
Annotatsiya
The relationship between mold and asthma has been recognized for decades, but the molecular triggers of asthma generated by molds have not been fully elucidated. A glycolipid generated by Aspergillus species has recently been identified that triggers airway hyperreactivity via natural killer T cell activation. The synthesis of this glycolipid and structural variants designed to allow identification of the features of this glycolipid required for recognition by natural killer T cells is described.
Hali tarjima qilinmagan
Identifikatorlar
Iqtiboslar va manbalar
2 ta iqtibos0 ta foydalanilgan manba