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A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng ZhouWuhan Institute of VirologyXing‐Lou YangWuhan Institute of VirologyXian-Guang WangUniversity of Chinese Academy of Sciences, Beijing, ChinaBen HuWuhan Institute of VirologyLei ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaWei ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaHao-Rui SiUniversity of Chinese Academy of SciencesYan ZhuWuhan Institute of VirologyBei LiCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaChao-Lin HuangWuhan Jin Yin-Tan Hospital, Wuhan, ChinaHuidong ChenWuhan Jin Yin-Tan Hospital, Wuhan, ChinaJing ChenUniversity of Chinese Academy of SciencesYun LuoUniversity of Chinese Academy of SciencesHua GuoUniversity of Chinese Academy of SciencesRen-Di JiangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaMei-Qin LiuUniversity of Chinese Academy of Sciences, Beijing, ChinaYing ChenUniversity of Chinese Academy of SciencesXu-Rui ShenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaXi WangWuhan Jin Yin-Tan Hospital, Wuhan, ChinaXiao-Shuang ZhengUniversity of Chinese Academy of SciencesKai ZhaoUniversity of Chinese Academy of SciencesQuan-Jiao ChenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaFēi DèngCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaLinlin LiuHubei Provincial Center for Disease Control and Prevention, Wuhan, ChinaBing YanCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaFa-Xian ZhanHubei Provincial Center for Disease Control and Prevention, Wuhan, ChinaYanyi WangWuhan Institute of VirologyGengfu XiaoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, ChinaZheng‐Li ShiCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

2020en

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Litsenziya: cc-by

ABI

Annotatsiya

Abstract Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of . In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.

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Identifikatorlar

DOI: 10.1038/s41586-020-2012-7

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