Biological properties of extracellular vesicles and their physiological functions
María Yáñez‐MóUnidad de Investigación Hospital Sta Cristina Instituto de Investigaciones Sanitarias Princesa (IIS‐IP) Madrid SpainPia SiljanderDivision of Pharmaceutical Biosciences Faculty of Pharmacy University of Helsinki Helsinki FinlandZoraida AndreuDepartamento de Biología Molecular UAM Madrid SpainApolonija Bedina ZavecLaboratory for Molecular Biology and Nanobiotechnology National Institute of Chemistry Ljubljana SloveniaFrancesc E. BorràsIVECAT Group – “Germans Trias i Pujol” Research Institute Badalona SpainEdit I. BuzásDepartment of Genetics, Cell‐ and Immunobiology Semmelweis University Budapest HungaryKrisztina BuzásFaculty of Dentistry University of Szeged Szeged HungaryEnriqueta CasalMetabolomics Unit CIC bioGUNE, CIBERehd Bizkaia Technology Park Derio SpainFrancesco CappelloEuro‐Mediterranean Institute of Science and Technology Palermo ItalyJoana CarvalhoInstituto de Investigação e Inovação em Saúde Universidade do Porto Porto PortugalEva ColásResearch Unit in Biomedicine and Translational Oncology Vall Hebron Institute of Research and Autonomous University of Barcelona Barcelona SpainAnabela Cordeiro‐da‐SilvaDepartment of Biological Sciences Faculty of Pharmacy University of Porto Porto PortugalStefano FaisAnti‐Tumour Drugs Section Department of Therapeutic Research and Medicines Evaluation National Institute of Health (ISS) Rome ItalyJuan Manuel Falcón‐PérezIKERBASQUE Basque Foundation for Science Bilbao SpainIrene M. GhobrialDana‐Farber Cancer Institute Boston MA USABernd GiebelInstitute for Transfusion Medicine University Hospital Essen University of Duisburg‐Essen Essen GermanyMario GimonaDepartment of Blood Group Serology and Transfusion Medicine Universitätsklinikum Salzburger Landeskliniken GesmbH (SALK) Salzburg AustriaMichael W. GranerDepartment of Neurosurgery University of Colorado Denver CO USAİhsan GürselDepartment of Molecular Biology and Genetics Thorlab‐Therapeutic Oligonucleotide Research Lab Bilkent University Ankara TurkeyMayda GürselDepartment of Biological Sciences Middle East Technical University Ankara TurkeyNiels H. H. HeegaardDepartment of Clinical Biochemistry and Pharmacology Odense University Hospital University of Southern Denmark Odense DenmarkAn HendrixLaboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, BelgiumPeter KierulfBood Cell Research Group Department of Medical Biochemistry Oslo University Hospital Oslo NorwayKatsutoshi KokubunDana‐Farber Cancer Institute Boston MA USAMaja KosanovićDepartment of Immunochemistry and Glycobiology Institute for the Application of Nuclear Energy, INEP University of Belgrade Belgrade SerbiaVeronika Kralj‐IgličLaboratory of Clinical Biophysics Faculty of Health Sciences University of Ljubljana Ljubljana SloveniaEva‐Maria Krämer‐AlbersMolecular Cell Biology and Focus Program Translational Neurosciences University of Mainz Mainz GermanySaara LaitinenResearch and Cell Services Finnish Red Cross Blood Service Helsinki FinlandCecilia LässerKrefting Research Centre Institute of Medicine at the Sahlgrenska Academy University of Gothenburg Gothenburg SwedenThomas LenerDepartment of Blood Group Serology and Transfusion Medicine Universitätsklinikum Salzburger Landeskliniken GesmbH (SALK) Salzburg AustriaErzsébet LigetiDepartment of Physiology Semmelweis University Budapest HungaryAija LinēLatvian Biomedical Research and Study Centre Riga LatviaGeorg LippsInstitute of Chemistry and Bioanalytics School of Life Sciences University of Applied Sciences and Arts Northwestern Switzerland Muttenz SwitzerlandAlicia LlorenteDepartment of Molecular Cell Biology Institute for Cancer Research Oslo University Hospital – The Norwegian Radium Hospital Oslo NorwayJan LötvallKrefting Research Centre Institute of Medicine at the Sahlgrenska Academy University of Gothenburg Gothenburg SwedenMateja Manček‐KeberNational Institute of Chemistry Laboratory of Biotechnology Ljubljana SloveniaAntonio MarcillaDepartamento de Biología Celular y Parasitologia Facultat de Farmacia Universitat de Valencia Valencia SpainMarı́a MittelbrunnDepartment of Vascular Biology and Inflammation Centro Nacional de Investigaciones Cardiovasculares Madrid SpainIrina NazarenkoInstitute for Environmental Health Sciences and Hospital Infection Control Medical Center – University of Freiburg Freiburg im Breisgau GermanyEsther N. M. Nolte‐‘t HoenDepartment of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsTuula A. NymanInstitute of Biotechnology, (Viikinkaari 1) University of Helsinki Helsinki FinlandLorraine O’DriscollSchool of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute Trinity College Dublin Dublin IrelandMireia OlivánResearch Unit in Biomedicine and Translational Oncology Vall Hebron Institute of Research and Autonomous University of Barcelona Barcelona SpainCarla OliveíraExpression Regulation in Cancer Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) Porto PortugalÉva PállingerDepartment of Genetics, Cell‐ and Immunobiology Semmelweis University Budapest HungaryHernando A. del PortilloInstitució Catalana de Recerca I Estudis Avançats Barcelona SpainJaume ReventósDepartament de Ciències Bàsiques Universitat Internacional de Catalunya and Institut de Recerca Biomèdica de Bellvitge Barcelona SpainMarina RigauResearch Unit in Biomedicine and Translational Oncology Vall Hebron Institute of Research and Autonomous University of Barcelona Barcelona SpainEva RohdeDepartment of Blood Group Serology and Transfusion Medicine Universitätsklinikum Salzburger Landeskliniken GesmbH (SALK) Salzburg AustriaMarei SammarDepartment of Biotechnology Engineering ORT Braude College Karmiel IsraelFrancisco Sánchez‐MadridDepartment of Vascular Biology and Inflammation Centro Nacional de Investigaciones Cardiovasculares Madrid SpainNuno SantarémInstituto de Investigação e Inovação em Saúde Universidade do Porto Porto PortugalKatharina SchallmoserDepartment of Blood Group Serology and Transfusion Medicine Universitätsklinikum Salzburger Landeskliniken GesmbH (SALK) Salzburg AustriaMarie S. OstenfeldDepartmnet of Molecular Medicine Aarhus University Hospital Aarhus DenmarkWillem StoorvogelDepartment of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsRoman ŠtukeljLaboratory of Clinical Biophysics Faculty of Health Sciences University of Ljubljana Ljubljana SloveniaSusanne G. van der GreinDepartment of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsM. Helena VasconcelosDepartment of Biological Sciences Faculty of Pharmacy University of Porto (FFUP) Porto PortugalMarca H. M. WaubenDepartment of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsOlivier De WeverLaboratory of Experimental Cancer Research Department of Radiation Oncology and Experimental Cancer Research Ghent University Hospital Ghent Belgium
2015en
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Annotatsiya
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV‐mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd‐sourcing, drawing on the unique EV expertise of academia‐based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
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