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MiRNAs Derived from Cancer-Associated Fibroblasts in Colorectal Cancer

Amir SavardashtakiDepartment of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Shiraz University of Medical Sciences Shiraz, IranZahra ShabaninejadDepartment of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IranAhmad MovahedpourDepartment of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Shiraz University of Medical Sciences Shiraz, IranRoxana SahebnasaghDepartment of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranMichael R. HamblinMassachusetts General Hospital
2019en
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Litsenziya: cc-by

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Annotatsiya

Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.

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DOI
10.2217/epi-2019-0110

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