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Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation

Yadollah YaminiTehran University of Medical SciencesPardis KalantarianTehran University of Medical SciencesMohammad HojjatiDepartment of Chemistry, Tarbiat Modares University, Tehran, Iran, and Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAli EsrafilyTehran University of Medical SciencesMorteza MoradiDepartment of Chemistry, Tarbiat Modares University, Tehran, Iran, and Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAlireza VatanaraTehran University of Medical SciencesIsmaeil HarrianTehran University of Medical Sciences

2009en

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Annotatsiya

The solubilities of flutamide, dutasteride, and finasteride in supercritical carbon dioxide were investigated at temperatures of (308.0, 318.0, 328.0, 338.0, and 348.0) K and various pressures in the range of (12.1 to 35.5) MPa. The measured results were then correlated using semiempirical equations presented by Chrastil and Bartle. With optimally fitted parameters, the average absolute relative deviations (AARD) ranged from 0.122 to 0.260 and from 0.024 to 0.137 for Chrastil and Bartle models, respectively. The heat of drug−CO2 solvation and that of drug vaporization were approximated in the range of (−17.4 to −16.8) kJ·mol−1 and (73.7 to 90.1) kJ·mol−1, respectively.

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DOI: 10.1021/je900520a

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