SignalP 6.0 predicts all five types of signal peptides using protein language models
Felix TeufelDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, SwitzerlandJosé Juan Almagro ArmenterosNovo Nordisk FoundationAlexander Rosenberg JohansenDepartment of Computer Science, Stanford University, Stanford, CA, USAMagnús Halldór GíslasonRigshospitaletSilas Irby PihlSection for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, DenmarkKonstantinos D. TsirigosEMBL-EBI, Wellcome Genome Campus, Cambridge, UKOle WintherTechnical University of DenmarkSøren BrunakNovo Nordisk FoundationGunnar von HeijneScience for Life Laboratory, Stockholm University, Solna, SwedenHenrik NielsenSection for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. [email protected]
2022en
ABI
Annotatsiya
Signal peptides (SPs) are short amino acid sequences that control protein secretion and translocation in all living organisms. SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs. We introduce SignalP 6.0, a machine learning model that detects all five SP types and is applicable to metagenomic data.
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