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Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

Melinda HamerWalter Reed Army Institute of Research, Silver Spring, MD, USA; Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USAKatherine V. HouserVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAAmelia R. HofstetterVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAAna M. Ortega‐VillaNational Institute of Allergy and Infectious DiseasesChristine LeeWalter Reed Army Institute of Research, Silver Spring, MD, USAAnne PrestonWalter Reed Army Institute of Research, Silver Spring, MD, USABrooke AugustineWalter Reed Army Institute of Research, Silver Spring, MD, USACharla AndrewsNational Institute of Allergy and Infectious DiseasesGalina V. YamshchikovVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USASomia P. HickmanNational Institute of Allergy and Infectious DiseasesSteven SchechHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAJack HutterWalter Reed Army Institute of Research, Silver Spring, MD, USAPaul T. ScottWalter Reed Army Institute of Research, Silver Spring, MD, USAPaige WatermanWalter Reed Army Institute of Research, Silver Spring, MD, USAMihret F. AmareHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAVictoria KiokoHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USACasey StormeHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAKayvon ModjarradWalter Reed Army Institute of Research, Silver Spring, MD, USAMelanie McCauleyHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAMerlin L. RobbHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USAMartin R. GaudinskiVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAIngelise J. GordonNational Institute of Allergy and Infectious DiseasesLaSonji A. HolmanNational Institute of Allergy and Infectious DiseasesAlicia T. WidgeNational Institute of Allergy and Infectious DiseasesLarisa StromVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAMyra HappeVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAJosephine H. CoxNational Institute of Allergy and Infectious DiseasesSandra VazquezVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USADaphne A. StanleyNational Institute of Allergy and Infectious DiseasesTamar MurrayNational Institute of Allergy and Infectious DiseasesCaitlyn N M DulanVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USARuth HunegnawVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USASandeep NarpalaVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAPhillip A. SwansonVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAManjula BasappaNational Institute of Allergy and Infectious DiseasesJagada ThillainathanNational Institute of Allergy and Infectious DiseasesMarcelino PadillaNational Institute of Allergy and Infectious DiseasesBritta FlachVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USASarah O’ConnellNational Institute of Allergy and Infectious DiseasesOlga TrofymenkoNational Institute of Allergy and Infectious DiseasesPatricia MorganNational Institute of Allergy and Infectious DiseasesEmily E. CoatesVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAJason G. GallNational Institute of Allergy and Infectious DiseasesAdrian B. McDermottVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USARichard A. KoupVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAJohn R. MascolaVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAAurélie PloquinNational Institute of Allergy and Infectious DiseasesNancy J. SullivanNational Institute of Allergy and Infectious DiseasesJulie A. AkeWalter Reed Army Institute of Research, Silver Spring, MD, USAJulie E. LedgerwoodVaccine Research Center, and Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USARebecca LampleyBrenda LarkinPamela CostnerHope WilsonMike Read
2023en
ABI

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