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Lanostanes from<i>Phellinus igniarius</i>and Their iNOS Inhibitory Activities

Guei-Jane WangNational Research Institute of Chinese Medicine, Taipei 112, TaiwanTung‐Hu TsaiNational Yang Ming Chiao Tung UniversityTun‐Tschu ChangDivision of Forest Protection, Taiwan Forestry Research Institute, Taipei, TaiwanCheng‐Jen ChouNational Research Institute of Chinese Medicine, Taipei, TaiwanLie-Chwen LinNational Yang-Ming University

2009en

ABI

Annotatsiya

Four new lanostanol-type triterpenoids, igniarens A - D ( 1- 4), were isolated from the fruit body of Phellinus igniarius together with two known triterpenoids, and two known ergostanes. These four new compounds were identified by spectroscopic analysis as 22 R-hydroxy-24-methylene-29-norlanost-7, 9(11)-dien-3-one (1), 3alpha,22 R-dihydroxy-24-methylene-29-norlanost-7, 9(11)-diene (2), 3alpha,22 R-dihydroxy-24-methylene-29-norlanost-8-ene ( 3), and 3alpha,22 R-dihydroxy-24-methylenelanost-8-ene ( 4). Their effects on NO production in lipopolysaccharide (LPS)-activated macrophages were assessed. Compounds 1- 8 inhibited NO production in activated RAW 264.7 cells to various degrees. The most potent compound 5alpha,8alpha-epidioxy-22 E-ergosta-6,22-dien-3beta-ol ( 7) significantly inhibited LPS-induced NO production in a concentration-dependent manner without affecting the cellular viability, with an IC (50) of 37.57 +/- 1.38 microM.

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Identifikatorlar

DOI: 10.1055/s-0029-1185813

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