The Image Biomarker Standardization Initiative: Standardized Convolutional Filters for Reproducible Radiomics and Enhanced Clinical Insights
P. WhybraUniversity Hospital HeidelbergAlex ZwanenburgFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QVincent AndrearczykUniversity Hospital HeidelbergRoger SchaerUniversity Hospital HeidelbergAditya ApteUniversity Hospital HeidelbergAlexandre AyotteUniversity Hospital Carl Gustav CarusBhakti BahetiUniversity Hospital HeidelbergSpyridon BakasUniversity Hospital Carl Gustav CarusAndrea BettinelliFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QRonald BoellaardUniversity Hospital HeidelbergLuca BoldriniUniversity Hospital HeidelbergIrène BuvatUniversity Hospital Carl Gustav CarusGary CookUniversity Hospital HeidelbergFlorian DietscheUniversity Hospital Carl Gustav CarusN. DinapoliUniversity Hospital HeidelbergHubert S. GabryśUniversity Hospital HeidelbergVicky GohUniversity Hospital HeidelbergMatthias GückenbergerUniversity Hospital HeidelbergMathieu HattUniversity Hospital HeidelbergMahdi HosseinzadehUniversity Hospital Carl Gustav CarusAditi IyerUniversity Hospital Carl Gustav CarusJacopo LenkowiczUniversity Hospital Carl Gustav CarusMahdi Ait Lhaj LoutfiUniversity Hospital HeidelbergSteffen LöckFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFrancesca MarturanoUniversity Hospital HeidelbergOlivier MorinUniversity Hospital HeidelbergChristophe NiocheUniversity Hospital Carl Gustav CarusFanny OrlhacFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QSarthak PatiFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QArman RahmimUniversity Hospital HeidelbergSeyed Masoud RezaeijoFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QChristopher G RookyardFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMohammad R. SalmanpourFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAndreas SchindeleUniversity Hospital Carl Gustav CarusIsaac ShiriUniversity Hospital Carl Gustav CarusEmiliano SpeziFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QStephanie Tanadini‐LangUniversity Hospital HeidelbergFlorent TixierUniversity Hospital Carl Gustav CarusTaman UpadhayaFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QVincenzo ValentiniUniversity Hospital Carl Gustav CarusJoost J. M. van GriethuysenFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFereshteh YousefiriziFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QHabib ZaidiFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QHenning MüllerFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMartin VallièresUniversity Hospital HeidelbergAdrien DepeursingeUniversity Hospital Heidelberg
2024en
ABI
Annotatsiya
Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters. The first two phases focused on finding reference filtered images and reference feature values for commonly used convolutional filters: mean, Laplacian of Gaussian, Laws and Gabor kernels, separable and nonseparable wavelets (including decomposed forms), and Riesz transformations. In the first phase, 15 teams used digital phantoms to establish 33 reference filtered images of 36 filter configurations. In phase 2, 11 teams used a chest CT image to derive reference values for 323 of 396 features computed from filtered images using 22 filter and image processing configurations. Reference filtered images and feature values for Riesz transformations were not established. Reproducibility of standardized convolutional filters was validated on a public data set of multimodal imaging (CT, fluorodeoxyglucose PET, and T1-weighted MRI) in 51 patients with soft-tissue sarcoma. At validation, reproducibility of 486 features computed from filtered images using nine configurations × three imaging modalities was assessed using the lower bounds of 95% CIs of intraclass correlation coefficients. Out of 486 features, 458 were found to be reproducible across nine teams with lower bounds of 95% CIs of intraclass correlation coefficients greater than 0.75. In conclusion, eight filter types were standardized with reference filtered images and reference feature values for verifying and calibrating radiomics software packages. A web-based tool is available for compliance checking.
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