Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation
Haonan LiState Key Laboratory of BiotherapyQiang LuoState Key Laboratory of BiotherapyHu ZhangKeck Graduate InstituteXuelei MaDepartment of Radiology, Department of Biotherapy, Huaxi MR Research Center (HMRRC), Cancer Center, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, ChinaZhongwei GuState Key Laboratory of BiotherapyQiyong GongState Key Laboratory of BiotherapyKui LuoFunctional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu 610041, China
2022en
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vaccination, promoting immunogenic cell death, overcoming radiation resistance, reversing immunosuppression, as well as pre-stratifying patients and assessing therapeutic response or therapy-induced toxicity. Overall, this review aims to provide a comprehensive landscape of nanomedicine-assisted radio-immunotherapy. The underlying working principles and the corresponding design strategies for these nanomedicines are elaborated by following the concept of "from bench to clinic". Their state-of-the-art applications, concerns over their clinical translation, along with perspectives are covered.
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