Maqola

KDR Kinase Inhibitor Isolated from the Mushroom <i>Boletopsis leucomelas</i>

Akira KanekoDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanMariko TsukadaDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanMiyuki FukaiDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanToshihiro SuzukiKindai UniversityKazuto NishioDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanKazuhiko MikiDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanKaoru KinoshitaDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanKunio TakahashiDepartment of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, Department of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, and Department of Genome Biology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama-shi, Osaka 589-8511, JapanKiyotaka KoyamaKindai University

2010en

ABI

Annotatsiya

Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC(50) value of 70.7 microM. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC(50) value of 9.04 microM.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1021/np100113e

Iqtiboslar va manbalar

3 ta iqtibos0 ta foydalanilgan manba