Fragment-based approach to novel bioactive purine derivatives
В. П. КрасновUral Federal University named after the first President of Russia B N Yeltsin, Institute of Chemical Engineering , Yekaterinburg, 620002 , RussiaГалина Л. ЛевитUral Branch of the Russian Academy of SciencesVera V. MusiyakUral Branch of the Russian Academy of SciencesDmitry А. GruzdevUral Branch of the Russian Academy of SciencesValery N. CharushinRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , Russia
2020en
ABI
Annotatsiya
Abstract Using purine as a scaffold, the methods for preparation of novel 2-aminopurine and purine derivatives substituted at position C 6 by the fragments of natural amino acids, short peptides, and N -heterocycles, including enantiopure ones, have been proposed. The methods for determination of the enantiomeric purity of the obtained chiral compounds have been developed. Conjugates exhibiting high antimycobacterial or anti-herpesvirus activity against both laboratory and multidrug-resistant strains were revealed among the obtained compounds.
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