YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation
Yukihide IwamotoNational Institute of Dental and Craniofacial ResearchFrank A. RobeyUnited States Food and Drug AdministrationJeannette GrafNational Institute of Dental and Craniofacial ResearchMakoto SasakiLaboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892Hynda K. KleinmanLaboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892Yoshihiko YamadaLaboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892George R. MartinLaboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
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The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro.
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