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The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment

Yanping GaoNanjing UniversityBing FengDepartment of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaSiqi HanDepartment of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaKai ZhangNanjing UniversityJing ChenNanjing UniversityChen LiDepartment of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaRui WangDepartment of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaLongbang ChenNanjing University

2016en

ABI

Annotatsiya

Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications.

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DOI: 10.1159/000438641

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