Role of IL-10 in the progression of kidney disease
Inna SinuaniPathology Depart-ment, Assaf Harofeh Medical Center, Sackler Faculty of Medi-cine, Tel Aviv University, Haim Levanon 55, Zerifin 70300, IsraelIlia BeberashviliPathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, IsraelZhan AverbukhInna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, IsraelJudith SandbankInna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel
2013en
ABI
Annotatsiya
Interleukin-10 (IL-10), a cytokine with anti-inflammatory and immunomodulatory functions, regulates the biology of B and T cells. The present review describes the role of IL-10 in normal renal physiology, during acute kidney injury and in the development of chronic renal failure. We further discuss IL-10-induced cellular and molecular pathways and their link to the progression of kidney injury.
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