SARS-CoV-2 S1 oqsilini Saccharomyces cerevisiae hujayralarida rekombinant ekspressiya qilishni baholash
Toshboyeva Fotima Nuriddin qiziMirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetiAyubov M.S.Center of Genomics and Bioinformatics of the Academy of Sciences of the Republic of UzbekistanRavshanov Hamroqul To‘ymurod o‘g‘liMirzo Ulug‘bek nomidagi O‘zbekiston Milliy universiteti
2026en
Ochiq kirishOltin
Litsenziya: cc-by
ABI
Annotatsiya
This study analyzed a technological approach aimed at evaluating the recombinant expression of the SARS-CoV-2 S1 protein in Saccharomyces cerevisiae cells. The study considered an S. cerevisiae culture and an expression system based on the pYES2-S1-Zeo construct. SDS-PAGE and Western blot methods were intended for the detection of the recombinant protein. The molecular mass of the S1 protein, 61 kDa, was indicated as the main criterion for electrophoretic identification. The study focused on evaluating a recombinant antigen production platform, while the determination of final vaccine efficacy is to be carried out at a subsequent stage.
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